Reverse Genetic Analysis of the Recombination in Theilovirus based on the Infectious cDNA Clones
نویسندگان
چکیده
The genus Cardiovirus which belongs to the family Picornaviridae is divided into two species: Theilovirus and Encephalomyocarditis virus (EMCV). The natural hosts for Cardioviruses have been thought to be the rodents. However, in 2007, a human cardiovirus, designated Saffold virus (SAFV), was identified from an infant with a fever of unknown origin [1]. Its nucleotide sequences showed a strong similarity to Theiler-like rat virus (TRV), which was isolated from rats in Japan [2]. In the aid of phylogenetic analysis, SAFV was classified with TRV, Theiler’s murine encephalomyelitis virus (TMEV) and Vilyuisk human encephalomyelitis virus (VHEV) into the species Theilovirus and eight genotypes of SAFV have been reported [1, 3-6].
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